Monday, 24 July 2017
Pascual Sanz NUTRIENT-MEDIATED SIGNALING UNIT

Formación Académica

• Licenciado en Farmacia, Univ. Valencia, 1980.

• Doctor en Farmacia, Dept. Microbiología, Univ. Valencia, 1986.

 

Formación Profesional

• EMBL, Heidelberg, Germany; 1987.

• Dept. Biological Chemistry, UCLA, Los Angeles, USA; 1987-1989.

• Dept. Genetics and Development, Columbia Univ. New York, USA; 1998-1999.

 

Méritos

• Director del Instituto de Biomedicina de Valencia CSIC (Feb-2011).

• Profesor de Investigación del CSIC (Abr-2009).

• Responsable de la Unidad 742 del Centro de Investigación Biomédica en Red de Enfermedades Raras CIBERER (Sept-2006).

• Miembro del SubComité de Bioética del CSIC (Oct-2010).

• Miembro de la SEBBM. Coordinador del grupo de regulación metabólica (2005-2007).

 

Publicaciones destacadas

• Moreno, D., Towler, M.C., Hardie, D.G., Knecht, E. and Sanz, P. “The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains AMP-activated protein kinase beta subunits”. Mol. Biol. Cell 21, 2578-2588 (2010).

 

• Garcia-Haro, L., Garcia-Gimeno, M.A., Neumann, D., Beullens, M., Bollen, M. and Sanz, P. “The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphoporylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 b cells”. FASEB Journal, 24, 5080-5091 (2010).

 

• Criado, O., Aguado, C., Gayarre, J., Duran-Trio, L., Garcia-Cabrero, A.M., Vernia, S., San Millan, B., Heredia, M., Romá-Mateo, C., Mouron, S., Dominguez, M., Navarro, C., Serratosa, J.M., Sanchez, M., Sanz, P., Bovolenta, P., Knecht, E. and Rodriguez de Cordoba, S. “Lafora bodies and neurological defects in malin-deficient mice correlates with impaired autophagy”. Hum. Mol. Genet. 21, 1521-1533 (2012).

 

• Rubio, T., Vernia, S. and Sanz, P. “Sumoylation of AMPKb2 subunit enhances AMP-activated protein kinase activity”. Mol. Biol. Cell. 24, 1801-1811 (2013).

 

• Rubio-Villena, C., Garcia-Gimeno, M.A. and Sanz, P. “Glycogenic activity of R6, a protein phosphatase 1 regulatory subunit, is modulated by the laforin-malin complex”. Int. J. Biochem. Cell Biol. 45, 1479-1488 (2013).